The Organisation for an ethical and responsible Inserm research”) is a transversal project that involves all activities, all employees and all members of the Inserm/University joint units. This programme is part of the 2025 strategic plan of Inserm. The objective of LORIER is to encourage the development of a common culture of ethical and responsible research in order to go further in the respect of ethics and professional integrity, to improve the responsibility, transparency, reproducibility and quality of our research.” LORIER is Philippe Ravaud and co-directed by Ghislaine Filliatreau. LORIER is organized into different “working groups” and “scientific animation groups”. OSIRIS will be linked to the reproducibility and meta-research scientific animation groups.